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Literature summary extracted from

  • Li, D.; Yang, J.; Ma, H.; Sun, C.; Feng, R.
    Inositol polyphosphate-4-phosphatase type II and rucaparib treatment inhibit the growth of osteosarcoma cells dependent on phosphoinositide 3-kinase/protein kinase B pathway (2018), J. Cell. Biochem., 119, 9899-9909 .
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.66 medicine INPP4B is low expressed in osteosarcoma tissues and in osteosarcoma cell lines. INPP4B overexpression significantly decreases cell viability and induces apoptosis in SaOS2 and U2OS cells. Combination of INPP4B overexpression and poly-ADP ribose polymerase inhibitor rucaparib declines Myc, cyclin E1 and cyclin D1 expressions, enhances Bad, Bax, and cleaves caspase3 expressions, and blocks PI3K/AKT signal pathway in SaOS2 and U2OS cells. Combination of INPP4B overexpression and rucaparib inhibits tumor formation in vivo Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.153 quantitative RT-PCR enzyme expression analysis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.153 additional information a combination of INPP4B overexpression and rucaparib blocks the PI3K/AKT signal pathway Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.153 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.153 Homo sapiens
-
-
-
3.1.3.66 Homo sapiens O15327
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.153 osteosarcoma cell
-
 Homo sapiens
-
2.7.1.153 SAOS-2 cell
-
 Homo sapiens
-
2.7.1.153 U2-OS cell
-
 Homo sapiens
-
3.1.3.66 SAOS-2 cell
-
 Homo sapiens
-
3.1.3.66 U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase
-
 Homo sapiens
2.7.1.153 phosphoinositide 3-kinase
-
 Homo sapiens
3.1.3.66 INPP4B
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.153 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.153 malfunction a combination of INPP4B overexpression and rucaparib blocks the PI3K/AKT signal pathway Homo sapiens
2.7.1.153 metabolism inositol polyphosphate-4-phosphatase type II and rucaparib treatment inhibit the growth of osteosarcoma cells dependent on phosphoinositide 3-kinase/protein kinase B pathway, combined effects of INPP4B and rucaparib on cell cycle, apoptosis and phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) signal pathway. INPP4B plays an important role in the development of tumors, which can maintain the balance of internal inositol phosphate, suppress the activation of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT) signal pathway, and block cells malignant transformation Homo sapiens